Understanding the role of cell cycle regulation in stem cell regeneration during aging and mechanical unloading
This project aims to decipher the role of the cell cycle in regulating stem cell regeneration during disuse-based conditions and during aging. Our research demonstrates that specific cell cycle molecules inhibit stem cell regenerative capacity in a load-dependent manner.
Understanding the role of bone marrow stem cells and the bone marrow microenvironment in development of liver disease
Bone marrow derived macrophages can significantly affect the onset and progression of fibrotic liver disease. Our research focuses on the impact of stressors on the bone marrow microenvironment and stem cell niche and consequent effects on polarization of bone marrow monocytes.
Deciphering the impact of mechanical load and radiation on bone, joint, and immune health
Alterations in mechanical load are known to significantly affect both the musculoskeletal and immune systems. Our research uses the unique environment of spaceflight to assess the impact of altered load on bone, joint and immune health with a specific focus on the role of bone marrow stem cells.